Tomoscintigraphy for detecting gastrointestinal and medullary thyroid cancers: first clinical results using radiolabelled monoclonal antibodies against carcinoembryonic antigen.
C. Berchechief of radiation department and director of the Institut de Recherches de Radiobiologie Clinique Ludwig Institute for Cancer Research, 1066 Epalinges, Lausanne, SwitzerlandJ.-P. Machprofessor and head of nuclear medicine departmentJ. LumbrosoInstitut Gustave-Roussy and Institut de Recherches de Radiobiologie Clinique, F-94800 Villejuif, FranceCrystal S. Langlaischief of radiation department and director of the Institut de Recherches de Radiobiologie Clinique Ludwig Institute for Cancer Research, 1066 Epalinges, Lausanne, SwitzerlandFlorent AubryDepartment of Internal Medicine, University Hospital (Kantons-spital), Basel, SwitzerlandF. BucheggerDepartment of Internal Medicine, University Hospital (Kantons-spital), Basel, SwitzerlandS CarrelDepartment of Internal Medicine, University Hospital (Kantons-spital), Basel, SwitzerlandP RougierInstitut Gustave-Roussy and Institut de Recherches de Radiobiologie Clinique, F-94800 Villejuif, FranceC ParmentierInstitut Gustave-Roussy and Institut de Recherches de Radiobiologie Clinique, F-94800 Villejuif, FranceM Tubianaprofessor and head of nuclear medicine department
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Transaxial tomoscintigraphy (or single-photon emission computerised tomography) was used to detect secondary deposits of carcinoma in 17 patients who had been injected with iodine-131-labelled monoclonal antibodies against carcinoembryonic antigen. Of 17 tumor sites studied by tomoscintigraphy 16 were detected (sensitivity 94%); five sites had a volume smaller than 10 cm3. Tomoscintigraphy also detected three unknown tumour deposits later confirmed by surgery or radiology. In contrast, when 21 tumour sites in the same patients were studied by rectilinear scintigraphy, only nine tumour sites were detected (sensitivity 43%), of which eight had a volume larger than 50 cm3.
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