Production of <sup>11</sup>C‐labeled quinidine and tamoxifen
Dirk Van HaverLaboratory of Organic Chemistry, Krijgslaan, 281 (S. 4)T. VandewalleInstitute of Nuclear Sciences, Proeftuinstraat, 86Guido SlegersCarlo VandecasteeleInstitute of Nuclear Sciences, Proeftuinstraat, 86
Ochiq kirish: yoʻq
ABI
Annotatsiya
Abstract The production of [ 11 C] quinidine and [ 11 C] tamoxifen for use with positron emission tomography is described. The potassium salt of O‐desmethylquinidine and N‐desmethyltamoxifen free base are treated with [ 11 C]methyl iodide at 130°C for 10 min. After HPLC separation, the [ 11 C‐methyl]‐labeled compounds are produced with a radiochemical yield of 60 and 70 % respectively. Injectable activities from 50 to 70 mCi are obtained 1 h after the irradiation; the specific activity is 40–60 mCi/μ mole. The entire production is controlled by a microprocessor.
Hali tarjima qilinmagan