Subcutaneous Injection of Thallium-201 Chloride and Gallium-67 Citrate at Acupuncture Point K-3. An Animal Experiment and a Human-Being Study.

Subcutaneous (SC) injection of 99mTc pertechnetate (99mTc) at acupuncture points K-3 is a new method of lower-limb radionuclide venography. To investigate the mechanism of absorption of 99mTc from SC injected sites into vascular system, various radioisotopes such as 201Tl chloride (201T1) and 67Ga citrate (67Ga) were SC injected at K-3 points in animal and humanbeings experiments. It was found that 99mTc and 201Tl were absorbed rapidly from K-3 points through venous system and into whole body soft tissue. However, 67Ga with a larger effective ionic radius than 201Tl did not be absorbed throughout the observation of 5 minutes. Furthermore, intravenous administration of digitalis, a Na+-K+ pump blocker, did not inhibit the absorption of 99mTc and 201Tl after SC injection at K-3 points. These results suggest that absorption of radionuclides on SC injection at K-3 points is mainly through the passive pathway of diffusion rather than the active transport, and the effective ionic radius may be a major factor influencing the absorption rate of the radionuclides.

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