Relationship between collagen IV expression and biological behavior of gastric cancer

Conceivably the presence of basement membrane (BM) in a neoplasm might be a result of interaction of tumor cells with the extracellular matrix. Collagen IV is one of the major intrinsic components of BM. Recent study[1] has shown that collagen IV has cell adhesion function and is involved in the process of tumor invasion and metastasis, including colorectal cancer[2] and breast cancer. But there are few systematic studies on gastric cancer and the results are equivocal. In this study we evaluated the expression of collagen IV immunohistochemically in 148 advanced gastric cancer cases in an attempt to clarify the relationship between the patterns of expression and the biological behavior of gastric cancer.

Hali tarjima qilinmagan