Изучение фармакокинетики препарата Co-101 с использованием радионуклидного метода

The pharmacokinetics of a new medicinal preparation Co-101 in rats was studied by radionuclide techniques using a radioactive solution of 57 CoCl 2 for drug labeling. The radioactive isotope was obtained by means of cyclotron irradiation of a nickel target enriched with Ni-58 isotope. Radioactive cobalt-57 was introduced into the preparation at the stage of synthesis. Co-101 is slowly absorbed from gastrointestinal tract and distributed predominantly in the liver and blood. The labeled drug is excreted from the organism mainly with feces and party with urine, and in 24 h only ~7% of the initial dose is found in the organism.

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