Химический состав и фармакологическая активность листьев Pueraria hirsuta L., произрастающей в Грузии

Phenolic compounds contained in the leaves of Pueraria hirsuta L. growing in Georgia have been studied. Flavonolons robinin, rutin, and nicotinphlorin and isoflavone glycoside daidsin were isolated from the leaves, whereas isoflavons daidsin, daidsein, phormononetin, and ononin, and coumestane mirifucoumestane were isolated from the roots of the plant. Robinin predominates in the leaves with a yield of 1.7%. The dry extract from Pueraria hirsuta containing the entire complex of biologically active substances is capable of decreasing the contents of urea, residual nitrogen, and creatinine in blood serum both in intact rats and in rats with a model acute renal insufficiency caused by calomel (mercury dichloride). This extract is comparable in hypoazotemic activity with the well-known drug lespenephryl. The functional state of cytoplasmic reticulum in the monooxygenase system of renal cells plays a certain role in the mechanism of hypoazotemic activity of the plant extract.

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