Выделение, структурные исследования и противоязвенная активность леманина и аммотамнидина, выделенных из Ammothamnus lehmannii

Isolation and identification of chemical structure of lehmanin (flavanone) and ammothamnidin (chalkone) from Ammothamnus lehmanni Bunge are described. Their gastroprotective effect has been studied on models of stressor ulcers as well as ulcers induced by reserpine and butadion. It is established that per os administration of lehmanin and ammothamnidin (to more expressed degree) at a dose of 50 mg/kg for preceding 7 days decreases the intensity of destructive damage of gastric mucous membrane caused by the ulcerogenic agents. The antiulcer effect of lehmanin and ammothamnidin exceeds that of quercetin (flavonol).

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