Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells
Jitka ŠlegerováInstitute of Organic Chemistry and Biochemistry AS CR, v.v.iMiroslav HájekPrague 6, Czech RepublicIvan ŘehořPrague 6, Czech RepublicFrantišek SedlákInstitute of Organic Chemistry and Biochemistry AS CR, v.v.iJan ŠtursaNuclear Physics Institute AS CR, v.v.iMartin HrubýPrague 6, Czech RepublicPetr CíglerPrague 6, Czech Republic
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Core-shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for background-free near-infrared imaging of cancer cells. The particles showed excellent colloidal stability in buffers and culture media. After conjugation with a cyclic RGD peptide they selectively targeted integrin αvβ3 receptors on glioblastoma cells with high internalization efficacy.
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