Composition of statins produced by indigenous strain of Aspergillus terreus
T. G. GulyamovaDepartment of Biochemistry of Physiologically Active Compounds, Institute of Microbiology of the Academy of Sciences RU, UZBEKISTANS. M. NasmetovaDepartment of Biochemistry of Physiologically Active Compounds, Institute of Microbiology of the Academy of Sciences RU, UZBEKISTAND. M. RuzievaDepartment of Biochemistry of Physiologically Active Compounds, Institute of Microbiology of the Academy of Sciences RU, UZBEKISTANJF ZiyavitdinovDepartment of Chemistry of Proteins and Peptides, Institute of Bioorganic Chemistry of the Academy of Sciences RU, UZBEKISTANRS SattarovaDepartment of Biochemistry of Physiologically Active Compounds, Institute of Microbiology of the Academy of Sciences RU, UZBEKISTANG. A. RasulovaDepartment of Biochemistry of Physiologically Active Compounds, Institute of Microbiology of the Academy of Sciences RU, UZBEKISTAN
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Composition of statins produced by Aspergillus terreus 20 indigenous strain in submerged fermentation (SmF) has been studied. Identification of statin compounds in fungal extracts by LC-MS-MS analysis revealed 6 polyketide metabolites: lovastatin (LV) in lactone, acid and methyl ester forms, pravastatin (PV), monacolin L (ML) and simvastatin (SV). For the first time it has been revealed the ability producing simvastatin by A. terreus by direct fermentation.Keywords: Aspergillus terreus, statins, composition, HPLC, LC-MS-MS analysis, mass spectraInternational Journal of Engineering, Science and Technology Vol. 6, No. 1, 2014, pp. 71-76
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