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Google Glass-Directed Monitoring and Control of Microfluidic Biosensors and Actuators

Yu Shrike ZhangMassachusetts Institute of TechnologyFabio BusignaniMassachusetts Institute of TechnologyJoão RibasDoctoral Programme in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, PortugalJulio AlemanBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USATalles Nascimento RodriguesDivision of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, 02139, MA, USASeyed Ali Mousavi ShaeghBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USASolange MassaDivision of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Cambridge, 02139, MA, USACamilla Baj RossiBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USAIrene TaurinoIntegrated Systems Laboratory, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, SwitzerlandSu-Ryon ShinWyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02139, USAGiovanni CalzoneDepartment of Biomedical Engineering, Polytechnic University of Turin, Turin, ItalyGivan Mark AmaratungaInnovation Research CenterDouglas Leon ChambersHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USASaman JabariHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, 02139, MA, USAYuxi NiuZhejiang UniversityVijayan ManoharanMassachusetts Institute of TechnologyMehmet R. DokmeciBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USASandro CarraraIntegrated Systems Laboratory, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, SwitzerlandDanilo DemarchiDepartment of Electronics and Telecommunications, Politecnico di Torino, 10129 Torino, ItalyAli KhademhosseiniDepartment of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea

Scientific Reportsjournal2016en

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Litsenziya: cc-by

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Annotatsiya

Google Glass is a recently designed wearable device capable of displaying information in a smartphone-like hands-free format by wireless communication. The Glass also provides convenient control over remote devices, primarily enabled by voice recognition commands. These unique features of the Google Glass make it useful for medical and biomedical applications where hands-free experiences are strongly preferred. Here, we report for the first time, an integral set of hardware, firmware, software, and Glassware that enabled wireless transmission of sensor data onto the Google Glass for on-demand data visualization and real-time analysis. Additionally, the platform allowed the user to control outputs entered through the Glass, therefore achieving bi-directional Glass-device interfacing. Using this versatile platform, we demonstrated its capability in monitoring physical and physiological parameters such as temperature, pH, and morphology of liver- and heart-on-chips. Furthermore, we showed the capability to remotely introduce pharmaceutical compounds into a microfluidic human primary liver bioreactor at desired time points while monitoring their effects through the Glass. We believe that such an innovative platform, along with its concept, has set up a premise in wearable monitoring and controlling technology for a wide variety of applications in biomedicine.

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Mavzular

Innovative Microfluidic and Catalytic Techniques Innovation 3D Printing in Biomedical Research Microfluidic and Capillary Electrophoresis Applications

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DOI: 10.1038/srep22237

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