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A <sup>18</sup>F-labeled dibenzocyclooctyne (DBCO) derivative for copper-free click labeling of biomolecules

Kathrin KettenbachGermanyTobias L. RoßInstitute of Nuclear Chemistry

MedChemCommjournal2016en

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Litsenziya: cc-by

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Annotatsiya

The new prosthetic group <sup>18</sup>F-TEG-DBCO (dibenzocyclooctyne) can be prepared within a total reaction time of 60 min including purification with an overall yield (n.d.c.) of 34 ± 5%. Copper-free click cycloadditions with various biomolecule-azides resulted in very high RCYs under mild conditions.

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Mavzular

Click Chemistry and Applications Monoclonal and Polyclonal Antibodies Research Chemical Synthesis and Analysis

Identifikatorlar

DOI: 10.1039/c5md00508f

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