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Antibodies against NALP5 and it’s role in hypoparathyroidism in autoimmune polyglandular syndrome type 1

Leila SozaevaСозаева Лейла СалиховнаElizaveta OrlovaEndocrinology Research CenterОрлова Елизавета МихайловнаФГБУ Эндокринологический научный центр Минздрава России; ГБОУ ВПО «Первый Московский Государственный медицинский университет им. И.И. Сеченова» Минздрава РоссииBergithe Eikeland OftedalUniversity Of Bergen;Офтедаль БергиттTashkent Medical Academy Urgench BranchMaria KarevaКарева Мария АндреевнаValentina PeterkovaEndocrinology Research CenterПетеркова Валентина АлександровнаФГБУ Эндокринологический научный центр Минздрава России; ГБОУ ВПО «Первый Московский Государственный медицинский университет им. И.И. Сеченова» Минздрава РоссииИ. И. ДедовДедов Иван ИвановичEystein Sverre HusbyeUniversity Of Bergen;Хусби Эйстейн

2016en

Ochiq kirish: yoʻq

ABI

Annotatsiya

Hypoparathyroidism is one of major components of autoimmune polyglandular syndrome type 1 (APS type 1) with a prevalence 73—83%. The protein NALP5 has been described previously as an antigen of parathyroid glands. Aim — to investigate antibodies against NALP5 in patients with APS type 1. Material and methods . Seventy nine patients with APS type 1 were included in the study. Radio-immune assay was used for detecting antibodies against NALP5. Results . The correlation between hypoparathyroidism and high levels of antibodies against NALP5 was found (p<0.001). Sensitivity of the method was 69,4%, specificity — 83,3%, positive predictive value — 93,5%, negative predictive value — 44,1%. Correlations between other components of the disease and high levels of the antibodies were not found. Conclusions . We found a positive correlation between antibodies against NALP5 and hypoparathyroidism in APS type 1 patients. We did not find correlations between antibodies against NALP5 and other components of APS type 1.

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DOI: 10.14341/probl7803-5698

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