Amisulpride in Refractory Behavioral and Psychological Symptoms of Dementia

Annals of Alzheimer's and Dementia Care eertechz 001 olanzapine, quetiapine and risperidone.There are many patients who fail to respond to these drugs [9], leaving a window for the new entry [1].Since a sizable number of patients do not adequately respond to the available drugs [1,[9][10][11][12], drugs such as ramelteon [9] and carbamazepine [11] and blonanserin [12], have been tried.Even some radical treatments such as electroconvulsive treatment (ECT) and positive pressure ventilation [13], have been suggested [1], due to constraints in the use of available antipsychotics in BPSD [13].Though both typical and atypical antipsychotics have been used for management of BPSD; atypical antipsychotics [14,15], are commonly used in BPSD or in Mild Cognitive Impairments (MCI) [15], due to their lower incidence of adverse drug reactions (ADRs) compared to typical ones.The main difference between the two is in terms of their side effect profile specially with respect to extrapyramidal symptoms (EPS) such as acute dystonia, akathisia, parkinsonism and tardive dyskinesia [14], etc.It has been shown that antipsychotic usage can and reduce caregiver burden [16].Amisulpride is a second generation atypical antipsychotic that selectively binds to dopamine D 2 /D 3 receptors with 5-HT 7 antagonistic effect in the limbic system of the brain [14,15].Amisulpride has not

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