Features of the course of autoimmune hepatitis in children as a variant of autoimmune polyglandular syndrome

Autoimmune polyglandular syndrome is characterized by autoimmune damage to several endocrine glands, which can be combined with non-endocrine autoimmune disorders (connective tissue, hematological, gastrointestinal and other lesions). In autoimmune polyglandular syndrome (APS), the incidence of liver damage is 13–20%. Patients with this pathology need lifelong replacement therapy and dynamic observation by endocrinologists to monitor the effectiveness of treatment. Autoimmune hepatitis (AIG) is a chronic liver disease that affects mainly pre - and pubertal girls, characterized by hypergamaglobulinemia, autoantibody circulation, Association with human leukocyte antigens HLA DR3 or DR4, the presence of hepatitis during histological examination of the liver, and a positive response to immunosuppressive therapy.

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