Maqola

Chemical components of <i>Aconitum barbatum</i> var. <i>puberulum</i> and their cytotoxic and antibacterial activities

Nurfida AblajanState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Chinese Academy of Sciences, Urumqi, Xinjiang, P. R. ChinaBo ZhaoState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Chinese Academy of Sciences, Urumqi, Xinjiang, P. R. ChinaXue WenjuanXinjiang Institute of Ecology and GeographyJiangyu ZhaoXinjiang Institute of Ecology and GeographyШ. Ш. СагдуллаевS.Yu.Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, UzbekistanZou GuoanState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Chinese Academy of Sciences, Urumqi, Xinjiang, P. R. ChinaHaji Akber AisaState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Chinese Academy of Sciences, Urumqi, Xinjiang, P. R. China

Natural Product Researchjournal2021en

Ochiq kirish: yoʻq

ABI

Annotatsiya

Nineteen compounds, including seventeen alkaloids O-methylarmepavine (1), (S)6methoxy1(4methoxybenzyl)2methyl 1,2,3,4tetrahydroisoquinolin7ol (2), (+)-(IR,laR)-lahydroxymagnocurarin (3), (6R,6aS,P)-(+)-corydine (4), (+)-N-methyllaurotetanine (5), magnoflorine (6), 3-hydroxy-1,2-dimethoxy-5-methyl-5H-dibenzoindol-4-one (7), imperialine (8), crispine B (9), (S)-1-(3-methoxyphenyl)-N-methylpropan-2-amine (10), methyl 2- (acetamino)benzoate (11), 2-carboxyoxanilic acid methylester (12), 4-[2-(methoxycarbonyl) anilino]-4-oxobutanoic acid methyl ester (13), N-methylcorydaldine (14), N-methyl-6,7- dimethoxyisoquinolone (15), (5S,6R,7S,8R)-5-amino-(2Z,4Z)-1,2,3-trihybuta-2,4-dienyloxypentane- 6,7,8,9-tetraol (16), nicotinic acid (17), and two megastigmane type compounds, S(+)- dehydrovomifoliol (18) and megastigmane (19), were isolated from the Aconitum barbatum var. puberulum Ledeb. Compounds 1–3 and 5–19 were isolated from this plant for the first time, of which compound 11 was isolated from natural source for the first time. Cytotoxicity evaluation revealed that compound 5 displayed mild cytotoxicity against the Hela cell lines (IC50 13.69 ± 0.036 μM). Antibacterial activity evaluation revealed that compounds 1 and 6 showed strong antibacterial activity against the Gram-positive bacterium, S. aureus.

Hali tarjima qilinmagan

Mavzular

Plant-based Medicinal Research Alkaloids: synthesis and pharmacology Berberine and alkaloids research

Identifikatorlar

DOI: 10.1080/14786419.2021.2005050

Iqtiboslar va manbalar

0 ta iqtibos9 ta foydalanilgan manba