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Effects Of F-18 On KCL And Phenylephrine - Induced Contractions Of Rat Aorta

Abdisalim A. ZaripovInstitute Of Chemistry Of Plant Substances, Uzbek Academy Of Sciences, Tashkent, UzbekistanAdilbay T. EsimbetovInstitute Of Biophysics And Biochemistry, National University Of Uzbekistan, Tashkent, UzbekistanPulat B. UsmanovInstitute Of Chemistry Of Plant Substances, Uzbek Academy Of Sciences, Tashkent, UzbekistanDurdona ShokirovaSherzod ZhurakulovDurdona Shokirova Institute Of Biophysics And Biochemistry, National University Of Uzbekistan, Tashkent, Uzbekistan

The American Journal of Medical Sciences and Pharmaceutical Researchjournal2021en

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Litsenziya: cc-by

ABI

Annotatsiya

The mechanism of action of the alkaloid 1-(2´-bromine-4´,5´-dimethoxyphenyl) - 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) on the functional activity of smooth muscle cells of the rat aorta was studied. Isometric contraction activity was recorded using a Grass FT – 03 (Grass Instrument, USA) mechanotron. The relaxant effect of the F-18 alkaloid was found to be associated with blockade of Ca2 + (IP3R) channels in the SR, along with voltage- dependent and receptor-operated Ca2+channels in the aorta smooth muscle cell plasmalemma.

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Mavzular

Nitric Oxide and Endothelin Effects Eicosanoids and Hypertension Pharmacology Renin-Angiotensin System Studies

Identifikatorlar

DOI: 10.37547/tajmspr/volume03issue06-16

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