ASSESSMENT OF THE LEVEL OF ORGANOTROPIC AUTOANTIBODIES IN NEWBORNS WITH LOW BODY WEIGHT

The frequency of preterm birth is variable, but in most developed countries in recent decades it has been quite stable and amounts to 5-10% of the number of children born[18,29,35]. The frequency of adverse outcomes among surviving children born before 28 weeks of gestation reaches 40–50%, rising to 70–90% for children weighing 500.0–750.0 g[30,32,34,36]. In children born with low body weight, mortality reaches 30% [8,30]. The current level of development of perinatology makes it possible to increase the survival of these children, but the peculiarities of their subsequent growth and development require no less attention. [8]. The fact of premature birth of children in women with a burdened obstetric-gynecological and somatic history is associated with perinatal CNS damage and often with a change in the vegetative status of a child in the first years of life. [9,37,41]. In early childhood and in subsequent periods of development, these children show psychosomatic abnormalities, in particular nocturnal enuresis, prolonged low-grade fever, tics and obsessive movements, attention deficit hyperactivity disorder, tension cephalalgia, arterial hypertension, arterial hypotension, biliary dyskinesia, bronchial asthma, atopic dermatitis[27,39]. An inverse relationship has been shown between low birth weight and adult blood pressure levels, the likelihood of developing type 2 diabetes, cardiovascular disease, and an excessive response to stress [26,38]. Lack of motor development in children at 16 years of age is associated with body weight less than 2 kg at birth. [31]. IQ tests showed that 41% of children born at the 7th month of pregnancy had worse performance compared to their healthy peers and had learning problems [41]. Early preterm birth can negatively affect puberty and increase the chance of adolescent depression [16], as these children may slow down the process of myelination of the frontal lobe of the brain, which is responsible for motivation, satisfaction, short-term memory and vision. [35]. Studies conducted among adolescents born prematurely revealed anomalies in their brain development, namely, a lack of gray matter in the temporal brain and cerebellum

Hali tarjima qilinmagan