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MEMBRANE TECHNOLOGY IN THE EXTRACTION OF INDOLE ALKALOIDS

V. Yu. VachnadzeKutateladze Institute of Pharmacochemistry,NINA VACHNADZETbilisi State Medical University,Aliosha BakuridzeTbilisi State Medical University ,RAUL GOCIRIDZEBatumi Shota Rustaveli State UniversityMalkhaz JokhadzeTbilisi State Medical University ,VAXTANG MSHVILDADZEKutateladze Institute of Pharmacochemistry,Lamzira EbralidzeTbilisi State Medical University ,Dali BerashviliTbilisi State Medical University ,

2022en

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ABI

Annotatsiya

By using ultrafiltration membrane with a certain porosity, it is possible to achieve selective fractionation of dimeric and monomeric alkaloids at the molecular weight level. With porosity of the membrane 100-150A° and filtration of alcohol extracts of Vinca rosea L. obtained from the aerial part of the plant, selective fractionation was achieved within the molecular masses from M+ 168 to M+ 426. In the fraction of minor alkaloids, a norharman (M+ 168), dihydrositsirikin (M+ 356) and vindorosine (M+ 426) were identified by the method of LC-MS/MS and GC/MS. The fraction of the minor alkaloids showed strong cytotoxic activity against the DLD-1 and WS-1 cell lines (Resazurin test), and according to the Hoechst test, to the cells of all A-549, DLD-1 and WS-1 lines.

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Identifikatorlar

DOI: 10.52340/jecm.2022.723

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