Study of the effect of alkaloids isolated from the Vinca erecta plant on cardiac activity under experimental conditions
Yu. R. MirzaevAcademy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, UzbekistanT.T. KhamraevAcademy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, UzbekistanE.M. RuzimovAcademy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, UzbekistanB. N. KhandamovAcademy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, UzbekistanBotir AbduazimovAcademy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, UzbekistanSh.M. AdizovAcademy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, UzbekistanB.J. ElmurodovAcademy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, UzbekistanP. H. YuldashevAcademy of Sciences RUz Institute of Chemistry of Plant Substances, Tashkent, Uzbekistan
2022en
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In the presented research paper on the study of the effect of vincanine hydrochloride and its derivatives on cardiac activity, changes caused by the action of therapeutic and subtoxic doses of these substances are presented. Studies have shown that the studied substances slightly reduced the heart rate in therapeutic doses, while in high doses there was pronounced bradycardia and even death as a result of asystole. It was also found that the studied substances slightly reduces the generation of pulses at the sinus node in all studied doses, in high doses can even cause cardiac arrest.
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