ТАКАЯСУ КАСАЛЛИГИ ВА УЙҚУ ҚОН ТОМИРЛАРИНИ АТЕРОСКЛЕРОЗИДА МИЯ НЕЙРОТРОФИК ОМИЛИНИ ҚИЁСИЙ ТАҲЛИЛИ

Purpose of this study. The study of the level of brain‑ derived neurotrophic factor (MNF) in lacrimal fluid and blood plasma in Takayasu’s disease and atherosclerosis of the carotid arteries. Material and methods. We examined 28 patients and 10 practically healthy individuals aged 25 to 77 years, the average age was 45±0.5 years. The subjects were divided into 3 groups: group 1–15 patients with a confirmed diagnosis of nonspecific aortoarteritis (Takayasu’s disease); group 2–13 patients diagnosed with atherosclerosis of the carotid arteries; 3rd control group — consisted of 10 practically healthy individuals. All participants in the study underwent general ophthalmological examination methods, determination of the level of MNF in blood plasma and lacrimal fluid was performed by enzyme immunoassay (ELISA). Results. Analyzing the obtained data, it was found that the level of brain‑ derived neurotrophic factor in the blood plasma in the first group averaged 209.2±11.5 pg/ml, while in the second and third groups this figure was 68.2±7.7 pg/ml. ml and 56.4±4.8 pg/ml, respectively. Conclusion.Elevated levels of MNF in tear fluid and blood plasma may be an important early diagnostic sign of Takayasu’s disease.

Hali tarjima qilinmagan