ВЗАИМОСВЯЗЬ ПОКАЗАТЕЛЕЙ АНТИОКСИДАНТНОЙ ЗАЩИТЫ СЛЕЗНОЙ ЖИДКОСТИ И СТАДИЙ ДИАБЕТИЧЕСКОЙ РЕТИНОПАТИИ

Relevance. The aim of this study was to determine the correlation of indicators of nitric oxide and oxidative stress of the lacrimal fluid with the severity of non-proliferative diabetic retinopathy. Materials and methods. Clinical studies were conducted during the treatment of 36 patients (69 eyes) diagnosed with non-proliferative diabetic retinopathy (NDR). Patients underwent a general ophthalmological examination and biochemical studies of the lacrimal fluid. Results. Studies have shown a gradual decrease in nitric oxide levels as DR worsens. In patients with NDR 1a severity, the level of nitric oxide decreased statistically significantly by 22.3% (P<0.001), and in 1c severity this level decreased by 66.7% (P<0.001) relative to the values of practically healthy individuals and by 57.1% (P<0.001) compared with the indices of patients with 1a NDR severity. Conclusion. The severity of NDR is directly related to the level of nitric oxide in the lacrimal fluid of patients: as the content of nitric oxide decreases, progression of retinopathy is observed. The imbalance in the POL-AOS system has a staged character.

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