ДИАГНОСТИЧЕСКИЕ МАРКЕРЫ РАЗВИТИЯ И ПРОГРЕССИРОВАНИЯ ДИАБЕТИЧЕСКОЙ РЕТИНОПАТИИ

Annotation. Relevance. According to the literature, a pattern of increased activation of VEGF growth factors and a decrease in the level of BDNF in blood serum in the early stages of DR was revealed, which is a good diagnostic marker for detecting DR in the early stages. Purpose of the study. The aim of the study was to evaluate the relationship between the levels of vascular growth factor (VEGF) and brain-­derived neurotrophic factor (BDNF) in blood serum and the area of the foveal avascular zone (FAZ) on OCT-A in patients with type 2 diabetes mellitus (DM2), with various stages DR. Material and methods. A clinical study was conducted among 252 people (n=504), of wich 168 patients with type 2 diabetes and 84 healthy individuals, the average age of which was 57,6±7,8 years, of which 52,6% were men, 47,4% women. Results and conclusion. As a result of the study, it was proved that a mild BDNF deficiency in the SC less than 0.62 ng/ml indicates general DR, and a BDNF level <0.22 ng/ml indicates the development of PDR and/or diabetic macular ischemia (DMA).

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