Genital endometriosis: choice of therapy

Aromatase is a key enzyme in the conversion of androgens to estrogens in the ovaries and other tissues and organs. To study the role of aromatase in the pathogenesis of external genital endometriosis (NGE) 57 patients with NGE were examined and 15 healthy women of reproductive age. Aromatase activity was determined by the reaction of estrogens to the aromatase inhibitor letrozole. The ovarian source of the determined aromatase activity was determined by the suppression of the reaction to letrozole against the background of the use of the gonadotropin releasing hormone agonist. Aromatic activity in terms of antral. The follicle in patients with grade II–IV NE was higher than in healthy women, however, the total aromatic activity of the ovaries due to the low number of antral follicles did not differ from the indicator in the control group. Violation of folliculogenesis in NGE is probably associated with the revealed hyperestrogenemia of ovarian and extra-gonadal origin.

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