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Air cold atmospheric plasma with patterns for anaplastic squamous cell carcinoma treatment

Fan BaiInstitute of Biomedical and Health Engineering , Shenzhen Institute of Advanced Technology ,Yingjie LuYujie ZhiChina electronics standardization institute , Beijing 100007 , ChinaYueye HuangLong LiInstitute of Biomedical and Health Engineering , Shenzhen Institute of Advanced Technology ,Jiaoxiao LuoInstitute of Mechanics , Chinese Academy of Sciences , Beijing 100190 , ChinaJamoliddin RazzokovInstitute of Material Sciences , Academy of Sciences of the Republic of Uzbekistan , Chingiz Aytmatov 2b , Tashkent 100084 , UzbekistanO. A. KovalSiberian Branch of the Russian Academy of SciencesMaksudbek YusupovArifov Institute of Ion-Plasma and Laser Technologies , Academy of Sciences of the Republic of Uzbekistan , Durmon yuli 33 , Tashkent 100125 , UzbekistanGuojun ChenDepartment of Biomedical Engineering , McGill University , Montreal , Quebec H3A 1A3 , CanadaZhitong ChenInstitute of Biomedical and Health Engineering , Shenzhen Institute of Advanced Technology ,

2023en

Ochiq kirishYashil

Litsenziya: cc-by

ABI

Annotatsiya

In recent years, cold atmospheric plasma (CAP) using inert gas has been successfully applied for biomedicine, such as sterilization, wound healing, skin diseases, and tumor treatment. Here, we reported air cold atmospheric plasma with three different patterns (I. Non: basic square grid structure; II. Square: basic square grid structure + square node; III. Circle: basic square grid structure + circle node) for anaplastic squamous cell carcinoma treatment (VX2 cell line). Various plasma diagnostic techniques were applied to evaluate the physics of air CAP with patterns such as discharge voltage, plasma initial generating process, plasma temperature, and optical emission spectroscopy (OES). The direct effects of air CAP with patterns on anaplastic squamous cell carcinoma treatment (VX2 cell line) were investigated in vitro. We also studied the ROS (reactive oxygen species) and RNS (reactive nitrogen species) generation in cultured media released from VX2 cells after the treatment of air CAP with patterns. The results showed that the air CAP with circle-pattern generated more active substances during at 60s treatment time, which resulted in a higher death rate of VX2 cells. These initial observations establish the air CAP with patterns as potential clinical applications for cancer therapy.

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DOI: 10.48550/arxiv.2304.10380

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