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Measuring the Efficiency of Purging by non-random Mating in Human Populations

R. LaurentUniversité Paris CitéLaure GineauIRD, MERIT, Université Paris Cité , 75006 Paris , FranceJosé UtgeUniversité Paris CitéSophie LafosseEco-anthropologie (EA), Muséum National d'Histoire Naturelle, CNRS, Université Paris Cité , 75016 Paris , FranceChan Leakhena PhoeungRodolphe Mérieux Laboratory, University of Health Sciences , Phnom Penh , CambodiaTatyana HegayLaboratory of Genome-cell technology, Institute of Immunology and Human genomics, Academy of Sciences , Tashkent , UzbekistanRobert OlasoUniversité Paris-SaclayAnne BolandCentre National de Recherche en Génomique HumaineJean‐François DeleuzeCEA Paris-SaclayBruno ToupanceEco-Anthropologie, Université Paris Cité , 75006 Paris , FranceÉvelyne HeyerUniversité Paris CitéAnne‐Louise LeuteneggerUniversité Paris Cité , Inserm, NeuroDiderot, 75019 Paris , FranceRaphaëlle ChaixUniversité Paris Cité

Molecular Biology and Evolutionjournal2024en

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Litsenziya: cc-by-nc

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Annotatsiya

Human populations harbor a high concentration of deleterious genetic variants. Here, we tested the hypothesis that non-random mating practices affect the distribution of these variants, through exposure in the homozygous state, leading to their purging from the population gene pool. To do so, we produced whole-genome sequencing data for two pairs of Asian populations exhibiting different alliance rules and rates of inbreeding, but with similar effective population sizes. The results show that populations with higher rates of inbred matings do not purge deleterious variants more efficiently. Purging therefore has a low efficiency in human populations, and different mating practices lead to a similar mutational load.

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Genetic Associations and Epidemiology Genetic and phenotypic traits in livestock Genetic Syndromes and Imprinting

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DOI: 10.1093/molbev/msae094

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