SYNTHESIS OF SOME DERIVATIVES OF 2,3-TETRAMETHYLENE-3,4-DIHYDROQUINAZOLIN-4-ONE AND –THIONE

In the article a new method of reaction formylation of 2,3-tetramethylene-3,4-dihydroquinazolin-4-one (thione) with Vilsmeier-Haack reagent is carried out.It is established that from 2,3-tetramethylene-3,4-dihydroquinazolin-4-one α-formyl-2,3-tetramethylene-3,4-dihydroquinazolin-4-one is formed, and from 2,3-tetramethylene-3,4-dihydroquinazolin-4-thione α-hydroxymethylidene-2,3-tetramethylene-3,4-dihydroquinazolin-4-thione.Reactions of nucleophilic substitution of the obtained products are studied.Representatives of seleniumcontaining tricyclic quinazolin-4-ones and their thioanalogues with hydrogenated pyridine ring are synthesized for the first time.

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