Preclinical Evaluation of the PSMA/GRPR-Targeting Heterodimer [68Ga]Ga-BQ7812 for PET Imaging of Prostate Cancer: Advancing Toward Clinical Translation

Radioligands that target prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) have emerged as promising tools for both imaging and therapeutic strategies in prostate cancer. Yet, heterogeneous expression of these receptors in tumors and metastatic lesions can limit the effectiveness of single-target approaches. To address this limitation, dual-targeting radioligands capable of simultaneously binding PSMA and GRPR have been developed. In this study, we report th

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