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ANTI-RADICAL AND MEMBRANE-ACTIVE PROPERTIES OF GERANIIN POLYPHENOL COMPOUND

Dildora Rahmatullaevna IsamukhamedovaInstitute of Biophysics and Biochemistry under the National University of Uzbekistan, Tashkent, UzbekistanNurali ErgashevInstitute of Biophysics and Biochemistry under the National University of Uzbekistan, Tashkent, UzbekistanRahmatilla Nurullaevich RakhimovInstitute of Bioorganic Chemistry of the Academy of Sciences of the Republic of Uzbekistan, Tashkent, UzbekistanMuzaffar I. AsrarovInstitute of Biophysics and Biochemistry under the National University of Uzbekistan, Tashkent, Uzbekistan

2024en

Ochiq kirishOlmos

Litsenziya: cc-by

ABI

Annotatsiya

This research paper explores the anti-radical and membrane-active properties of geraniin polyphenol compound. Through experimentation, it was found that geraniin polyphenol exhibits a stabilizing effect on mitochondrial functional parameters and inhibits TssA-sensitive Sa2+-dependent mitochondrial megapore. Furthermore, the compound activates the permeability of the liver mitoK ATF channel and demonstrates membranotropic properties by regulating the size of the matrix. Notably, geraniin polyphenol showcases robust antiradical properties, indicating potent antioxidant activity. These findings shed light on the multifaceted pharmacological potential of geraniin polyphenol and its prospective applications in mitigating oxidative stress-related disorders.

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