IVF EVOLUTION IN UZBEKISTAN. FROM MULTIPLE EMBRYO TRANSFER ON DAY 3 TO ELECTIVE SINGLE EMBRO TRANSFER ON DAY 5 FOR BETTER NEONATAL OUTCOMES

IVF was officially permitted in Uzbekistan in 2019. Initially, the culture of embryos until the cleavage stage (days 2 to 3) with the transfer of multiple embryos was chosen for its speed and simplicity. Low cleavage stage transfer implantation rates led to multiple embryo transfers to achieve an acceptable clinical pregnancy rate, resulting in multiple pregnancies. A higher implantation rate with blastocyst stage transfer allows for the implementation of elective single embryo transfer as a standard of care, maintaining the clinical pregnancy rate while increasing singleton pregnancies and offering a safer approach to assisted reproduction technology treatment.

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