Maqola

Treatment of Parkinson’s Disease with an Anti-Inflammasome NLRP3 Inhibitor Derived from a Natural Product

Wenqian LiHuazhong Agricultural UniversityJiu‐liang ZhangHuazhong Agricultural UniversityQiang ChenInnovation Academy of International Traditional Chinese Medicinal MaterialsBiaobiao LuoCollege of pharmacyBo ZhouHuazhong Agricultural UniversityJun WangInnovation Academy of International Traditional Chinese Medicinal MaterialsYang YangInnovation Academy of International Traditional Chinese Medicinal MaterialsYi LiuCollege of InformaticsShuixiu WenHuazhong Agricultural UniversityKong DeCollege of InformaticsJian ChenHuazhong University of Science and TechnologyShaozhong WeiHubei Cancer Hospital, Tongji Medical College, Colorectal cancer clinical research center of Hubei Province, Colorectal cancer clinical research center of WuhanPierre DuezUniversity of Mons-UMONSAvez SharipovScientific Laboratory of Innovative Pharmaceutical Compounds, Tashkent Pharmaceutical Institute, Oybek Street 45, Tashkent 100015, UzbekistanYan LiInnovation Academy of International Traditional Chinese Medicinal MaterialsXuebo HuInstitute for Medicinal Plants, College of Plant Science and Technology

ACS Pharmacology & Translational Sciencejournal2025en

Ochiq kirishYashil

Manbada oʻqishpmc.ncbi.nlm.nih.gov(yangi oynada ochiladi)

ABI

Annotatsiya

experiments. The anti-inflammatory effects of ST-4 were evaluated in mouse models of chronic and progressive disorders, in which it showed significant efficacy in ameliorating obesity, type 2 diabetes, and peritonitis. In this study, the potential interest of ST-4 for the treatment of neuroinflammatory diseases was further investigated in a PD mouse model. ST-4 effectively suppressed the activation of the NLRP3 inflammasome induced by lipopolysaccharide in neuronal cells. Additionally, treatment with ST-4 significantly improved various aspects of PD pathology, including behavioral impairments, loss of dopaminergic neurons, alterations in cerebral neurophysiology, and dysregulated gene expression associated with metabolic dysfunction, highlighting its therapeutic potential for the treatment of Parkinson's disease.

Hali tarjima qilinmagan

Mavzular

Inflammasome and immune disorders Adenosine and Purinergic Signaling Parkinson's Disease Mechanisms and Treatments

Identifikatorlar

DOI: 10.1021/acsptsci.5c00109

Iqtiboslar va manbalar

0 ta iqtibos62 ta foydalanilgan manba