MORPHOLOGICAL CHANGES OF THE LIVER UNDER THE INFLUENCE OF LOW-CONCENTRATION ACETIC ACID IN ONE-MONTH-OLD OUTBRED WHITE RATS

Annotation: This article presents experimental findings showing that administration of 6% acetic acid without biocorrection caused significant morphological alterations in the liver parenchyma of albino rats. Histological observations revealed hepatocyte shrinkage, an increased nucleus-to-cytoplasm ratio, cytoplasmic vacuolization, venous stasis in central veins, dilation of interlobular vessels, sinusoidal deformation, and proliferative-dysplastic processes in the biliary epithelium. Overall, within one month, dystrophic, inflammatory, and compensatory changes developed simultaneously in the liver tissue. These results confirm the hepatotoxic effect of acetic acid and indicate the high sensitivity of hepatocytes in young organisms to this exposure.

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