DEVELOPMENT OF IONOPHORES FOR ION-SELECTIVE ELECTRODES FOR THE DETERMINATION OF MEDICINAL SUBSTANCES.

This article studies the synthesis and the properties of new ionophores used in the development of ion-selective electrodes (ISE) for the detection of drugs. In the course of the research, selective ionophores were created for the preparations dibazol, trimecaine and pyridoxine on the basis of dodecatungstophosphoric and dodecamolybdophosphoric acids. The synthesis processes, the methods of electrode preparation, the concentration of the solutions and the influence of pH were analysed in depth. These methods are inexpensive, easy to perform and highly accurate, and can therefore be widely applied in pharmaceutical analysis. On the basis of the results obtained, the practical significance of developing new selective electrodes was substantiated.

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