Changes in Biochemical Indicators During Alcoholic Intoxication

This study dynamically investigated the biochemical and physiological indicators of liver function and the overall metabolic state in rats under conditions of chronic ethanol intoxication. During the experiment, we assessed the activity of liver damage-indicating enzymes in the blood serum - ALT, AST, GGT, and alkaline phosphatase - as well as changes in the levels of albumin, total protein, glucose, triglycerides, and cholesterol. The results showed that chronic ethanol intoxication disrupts the structural-functional integrity of hepatocytes, leading to cytolysis, cholestasis, disorders of lipid and carbohydrate metabolism, and a decrease in the synthetic function of the liver. Furthermore, a decrease in body weight and an increase in the liver index in the experimental animals confirmed the escalating hepatotoxic effect of ethanol.

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