MORPHOLOGICAL CHANGES IN THE SMALL INTESTINE CAUSED BY DOMESTIC GAS POISONING AGAINST THE BACKGROUND OF CHRONIC ALCOHOLISM

Resume. The article analyzes the morphological, morphometric, and immunohistochemical changes occurring in the small intestine of outbred laboratory rats as a result of domestic gas poisoning against the background of chronic alcoholism. The study was conducted on 3-, 9-, and 15-month-old rats, which were divided into control, experimental, and correction groups. Morphological examinations revealed that the combined effects of chronic alcoholism and domestic gas exposure intensified destructive and dystrophic processes in the intestinal mucosa, leading to disruption of villous architecture, deformation of intestinal crypts, and pathological alterations in the microcirculatory bed. Immunohistochemical analysis demonstrated changes in proliferative activity and angiogenesis markers. Following corrective treatment, partial restoration of the structural organization of the intestinal mucosa was observed. Keywords: chronic alcoholism, domestic gas poisoning, small intestine, morphology, morphometry, immunohistochemistry, rat.

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