Maqola

Aqueous Extract of Luffa cylindrica: Modulation of Antibiotic Action and Antioxidant and Cytoprotective Evaluation

Isaac Moura AraújoRegional University of CaririJoão Arthur de Oliveira BorgesRegional University of CaririKamilla Bezerra MouraLucas Dos Santos SáRegional University of CaririLuís Pereira-de-MoraisRegional University of CaririCícera Georgia Brito MilfontRegional University of CaririEwerton Yago de Sousa RodriguesRegional University of CaririSheila Alves GonçalvesRegional University of CaririLeandro Marques CorreiaDr. Leão Sampaio University CenterJosé Thyálisson da Costa SilvaRegional University of CaririSara Tavares de Sousa MachadoRegional University of CaririFrancisco Isac Soares LeiteRegional University of CaririDanielle de Norões MotaMunicipal Health Department of CratoHallana De Lima TelesMunicipal Health Department of CratoJamilla Nogueira Landim RufinoDr. Leão Sampaio University CenterDébora Odília Duarte LeiteRegional University of CaririFabíola Fernandes Galvão RodriguesRegional University of Cariri

2026

Ochiq kirishOlmos

Litsenziya: cc-by

ABI

Annotatsiya

This study evaluated the antibacterial, antioxidant, and cytoprotective activities of the decoction from Luffa cylindrica fruits (DFLC). The aqueous extract was obtained by boiling the dried fruits, followed by lyophilization, and subjected to phytochemical screening and biological assays. Antibacterial and modulatory activities were investigated by broth microdilution against Staphylococcus aureus 10 and Escherichia coli 06, while cytotoxicity was assessed by hemolysis in erythrocytes and antioxidant activity by the DPPH method. DFLC did not exhibit direct antibacterial activity (MIC > 512 µg/mL), but reduced the MIC of norfloxacin against S. aureus, indicating a potential modulatory effect. The extract showed low cytotoxicity at lower concentrations and a progressive increase in hemolysis at higher doses. Antioxidant activity was modest compared to ascorbic acid. These results suggest that, although not inherently antimicrobial, DFLC may act as a potential adjuvant to antimicrobials and exhibits concentration-dependent biological effects.

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Identifikatorlar

DOI: 10.36560/19420262223

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