DEVELOPMENT AND CHARACTERIZATION OF BLACK SEED OIL LOADED MICRO SPONGES FOR THE MANAGEMENT OF VITILIGO

The present study aimed to develop and characterize black seed oil-loaded microsponges for the topical management of vitiligo. Black seed oil (Nigella sativa oil), known for its antioxidant and antiinflammatory properties, was incorporated into microsponge formulations using the quasi-emulsion solvent diffusion method. Different formulations were prepared by varying polymer concentration and evaluated for production yield, particle size, entrapment efficiency, surface morphology, in vitro drug release, and stability. The optimized formulation (F4) exhibited satisfactory physicochemical characteristics with high production yield (87.54 ± 1.11%), optimum particle size (82.6 ± 2.4 µm), and maximum entrapment efficiency (88.73 ± 1.06%). In vitro drug release studies demonstrated sustained release of black seed oil with 92.48 ± 1.24% drug release over 12 h. The optimized microsponge gel showed acceptable pH, viscosity, spreadability, and drug content suitable for topical application. Stability studies confirmed that the formulation remained stable without significant changes in physical appearance or drug content. The enhanced therapeutic potential of the developed formulation may be attributed to improved stability, controlled release, and enhanced skin retention of black seed oil. The findings suggest that black seed oil-loaded microsponges represent a promising topical delivery system for effective vitiligo management.

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