REPRODUCTIVE DYSFUNCTION IN MEN WITH THYROID DISORDERS: A PILOT CROSS-SECTIONAL STUDY FROM UZBEKISTAN

Resume. Thyroid hormones play a key role in male reproductive function, yet region-specific clinical data from Central Asia remain scarce. This single-center, cross-sectional pilot study evaluated hormonal and seminal parameters in 26 men aged 25–50 years: 8 with hypothyroidism, 13 with hyperthyroidism (6 anti-TPO–positive), and 5 euthyroid controls. Total testosterone, sperm concentration, and total motility were significantly reduced in both hypothyroid and hyperthyroid groups compared with controls, with the most pronounced impairment in anti-TPO–positive patients (67% with oligozoospermia and/or asthenozoospermia). These findings, the first such clinical dataset from Uzbekistan, support including thyroid function and anti-TPO testing in the standard work-up of male infertility. Keywords: thyroid dysfunction, hypothyroidism, hyperthyroidism, autoimmune thyroiditis, testosterone, semen analysis, male infertility, anti-TPO antibodies, Uzbekistan.

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