MODERN APPROACHES TO OXYGEN THERAPY: CLINICAL EFFICACY AND RISKS OF HYPEROXIA (A LITERATURE REVIEW)

Resume. This review examines the evolving scientific understanding of oxygen therapy over the past decade. For many years, supplemental oxygen administration was guided by the principle of "the more, the better." However, mounting evidence from both basic and clinical research has demonstrated that hyperoxia carries significant risks — particularly oxidative tissue stress and end-organ toxicity — alongside its well-documented benefits. This article synthesizes contemporary data on target oxygen saturation (SpO2) values across diverse clinical contexts, including acute myocardial infarction, ischemic stroke, and cardiopulmonary resuscitation. The emerging consensus favors a conservative, individualized approach over liberal oxygen supplementation, with implications for patient survival outcomes. Keywords: Oxygen therapy, hyperoxia, hypoxia, oxidative stress, SpO2, hyperbaric oxygenation, conservative medicine, resuscitation

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