Determination of the Anti-inflammatory Effective Dose of the Biologically Active Compound “Pulmaklin”

Pulmaklin is a flavonoid-rich supplement derived from traditional medicinal plants. This study evaluated the anti-inflammatory efficacy of the biologically active supplement "Pulmaklin" under experimental conditions. The effects of the preparation in syrup form at doses of 50 and 100 mg/kg were investigated, and the highest anti-exudative activity (AEA) was observed at 50 mg/kg, with a 54.3% reduction in edema development. Based on the results, the optimal dose of Pulmaklin was scientifically substantiated. Molecular-level analysis demonstrated that flavonoids, particularly the glycoside form rutin, exhibit the highest affinity toward the COX-2 enzyme due to their ability to form multiple interaction points. In addition, flavonoids such as rutin and quercetin showed effective modulation of IL-6 cytokine activity and MAPK signaling pathways, contributing to their anti-inflammatory effects. The findings confirm that flavonoids and their derivatives are promising natural bioactive compounds with significant anti-inflammatory potential.

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