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Evaluation of the Role of Plasmalemma Ca²+ Transport Systems in the Vasorelaxant Effect of the CAM-68 Alkaloid under In vitro Conditions

Sardor B. Sobirov1Department of Cell Biophysics, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanAbdisalim A. Zaripov5Department of Physiology and Pathology, Tashkent State Medical University, Tashkent, UzbekistanInoyat Z. Zhumaev1Department of Cell Biophysics, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanP. B. Usmanov1Department of Cell Biophysics, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanAdilbay T. EsimbetovShavkat Yu. Rustamov1Department of Cell Biophysics, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanSadriddin N. Boboev1Department of Cell Biophysics, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanGulnaz Sultanbayevna Begdullaeva3Department of Animal Anatomy and Physiology, Karakalpak State University named after Berdakh, Nukus, UzbekistanEldor B. Ibragimov1Department of Cell Biophysics, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanShakhnoza B. Qurbonova1Department of Cell Biophysics, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanSadoqat Abdukhalil qizi Safarova2Department of Alkaloids Chemistry,Institute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, Tashkent, UzbekistanSherzod ZhurakulovYunusov Institute of the Chemistry of Plant SubstancesDilbar D. Safarova4Department of Medical and Biological Sciences, Uzbek State University of Physical Education and Sports, Chirchiq, Uzbekistan

2026

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Annotatsiya

This study aims to evaluate how plasma membrane calcium transport mechanisms—specifically L-type calcium channels, receptor-operated calcium channels, and the sodium-calcium exchanger—contribute to the vasorelaxant activity of the alkaloid CAM-68. The isometric contraction force of the aortic rings was recorded using a Grass-Telefactor FT.03 myograph and analysed with the PowerLab data-acquisition software (ADInstruments). Findings indicate that the alkaloid CAM-68 exerts an effective vasorelaxant effect on vascular smooth muscle, which is primarily achieved by modulating intracellular Ca²⁺ concentration.The CAM-68 alkaloid inhibits voltage-dependent L-type Ca2+ channels and receptor-operated Ca2+ channels in the plasma membrane. It also attenuates the activity of the Na⁺/Ca²⁺ exchange in reverse mode. These effects are associated with the modulation of smooth muscle cell Ca²⁺ homeostasis and the attenuation of Ca²⁺ influx across the membrane.

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Identifikatorlar

DOI: 10.13005/bpj/3476

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