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Chiral Coumarin Enantiomers From <i>Prangos pabularia</i> Roots: Absolute Configuration, Tyrosinase Activation, and Anti‐Vitiligo Potential in B16F10 Cells

Sunbula AtolikshoevaKey Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi P. R. ChinaSodik NumonovResearch Institution “Chinese‐Tajik Innovation Center for Natural Products” National Academy of Sciences of Tajikistan Dushanbe TajikistanJun LiKey Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi P. R. ChinaJiangyu ZhaoKey Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi P. R. ChinaMayire NueraihemaitiKey Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi P. R. ChinaIsomiddin GulmurodovResearch Institution “Chinese‐Tajik Innovation Center for Natural Products” National Academy of Sciences of Tajikistan Dushanbe TajikistanXuelei XinKey Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi P. R. ChinaMaitinuer MaiwulanjiangKey Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi P. R. ChinaKhurshed BozorovDepartment of Medicinal Chemistry Institute of Biochemistry Samarkand State University Samarkand UzbekistanIbrohimjon AskarovDepartment of Chemistry Andijan State University Andijan UzbekistanGuangmin YaoKey Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi P. R. ChinaHaji Akber AisaKey Laboratory of Plant Resources and Chemistry in Arid Regions Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi P. R. China

2026en

Ochiq kirishYashil

Manbada oʻqishpmc.ncbi.nlm.nih.gov(yangi oynada ochiladi)

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Annotatsiya

ABSTRACT In order to isolate and characterize enantiomeric compounds from the roots of Prangos pabularia the dichloromethane extract was extensively fractionated by column chromatography, flash, semi‐preparative high performance liquid chromatography (HPLC), and chiral HPLC. Six pairs of enantiomers were isolated from dichloromethane extracts using preparative chiral HPLC. The absolute configurations of the isolated isomers were identified using circular dichroism (CD). The anti‐vitiligo activities of the corresponding (S)‐ and (R) ‐enantiomers were assessed by determining their tyrosinase activation rates. ( S )‐Pangelin 9 (PPE19‐1) showed higher activity with 125.42% than ( R )‐pangelin 10 (PPE19‐2) with 120.6%, while the positive control (8‐methoxypsoralen) resulted in 122.3%. The percentage of activation rate of ( S )‐oxypeucidanin hydrate 1 (PPE4‐1) was 119.74%, while it was 110.01% for ( R ) oxypeucidanin hydrate 2 (PPE4‐2). We conclude that the ( S, R ) enantiomers of pangelin and oxypeucidanin hydrate ( S, R ) may be useful as pigmentation‐promoting agents for the treatment of vitiligo.

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Identifikatorlar

DOI: 10.1002/cbdv.71537

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