STUDY OF MORPHOLOGICAL CHANGES IN THE CORTICAL LAYER OF THE FRONTAL REGION OF THE CEREBRAL HEMISPHERES IN 18-MONTH-OLD WHITE OUTBRED RATS AFTER PHYTOCORRECTION USING MILK THISTLE FOLLOWING EXPERIMENTAL CARBON MONOXIDE POISONING

This study investigated the morphological and morphometric state of the frontal cortex of the cerebral hemispheres in 18-month-old outbred white rats under carbon monoxide exposure, as well as the morphofunctional effectiveness of phytocorrection based on the plant milk thistle. Histological examinations were performed using hematoxylin-eosin staining, with assessment of the structural state of neurocytes, glial elements, and the microcirculatory bed. Carbon monoxide exposure induced pronounced hypoxic-dystrophic neuronal damage, manifested by decreased neuronal density and atrophic changes in cortical layers. In the phytocorrection group, while the neuronal population was preserved, a tendency toward morphological stabilization, a reduction in the degree of gliosis, and partial restoration of dendritic structures were observed. The obtained results indicate the neuroprotective and membrane-stabilizing effects of biologically active compounds of milk thistle.

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