Analysis of urolithiasis prevalence in the Republic of Uzbekistan in the 21st century

BACKGROUND: Urolithiasis is one of the most common urological diseases in Uzbekistan, as the region is endemic. Studying the primary and overall incidence of urolithiasis in Uzbekistan and comparing it with other countries is a pressing issue. AIM: To analyze trends in the incidence of urolithiasis in the Republic of Uzbekistan from 2000 to 2019. METHODS: Using data from the Ministry of Health of the Republic of Uzbekistan, we studied primary and overall morbidity in individual regions of Uzbekistan in the general and pediatric populations, compared morbidity between the Russian Federation and Uzbekistan, and performed a correlation analysis with the incidence of gout, diabetes mellitus, gastrointestinal diseases, and obesity. RESULTS: The incidence of urolithiasis increased steadily from 43,802 cases in 2000 to 104,364 cases in 2019. The primary incidence rate was 66.5 per 100,000 population in 2000 and 116.1 in 2019. The highest incidence was consistently in the Syrdarya region (over 500 cases per year). Correlation analysis revealed a statistically significant positive association with gout, obesity, gastrointestinal diseases, and diabetes. CONCLUSION: These data show a progressive increase in primary and overall urolithiasis incidence in Uzbekistan. Further study of local factors contributing to regional heterogeneity is needed.

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