SYNTHESIS AND CHARACTERIZATION OF CARBOXYMETHYLCELLULOSE–SERICIN HYDROGEL REINFORCED WITH SILVER–BISMUTH BIMETALLIC NANOPARTICLES

In this study, a biocomposite hydrogel was synthesized based on purified sodium carboxymethylcellulose (Na-CMC) with a degree of substitution (DS) of 0.88 and a degree of polymerization (DP) of 850, together with sericin obtained from natural silk. The physicochemical properties of the obtained hydrogel were investigated: electrostatic interactions between the carboxyl (–COO⁻) groups of Na-CMC and the amide I and amide II groups of sericin macromolecules were identified in the FTIR spectrum within the range of 1600-1700 cm⁻¹. Rheological studies confirmed that intermolecular crosslinking between the functional groups of Na-CMC and sericin led to a proportional increase in the viscosity of the hydrogel. After lyophilization of the Na-CMC/sericin hydrogel, scanning electron microscopy (SEM) revealed a porous structure with pore sizes ranging from 20 to 110 μm. The synthesized Na-CMC/sericin biocomposites hydrogel containing stable Ag–Bi bimetallic nanoparticles with sizes of 5–160 nm demonstrate strong potential for application in medical practice as non-surgical therapeutic biomaterials for the treatment of gastric and duodenal ulcer disease.

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