Additional effect of a drug containing estetrol and drospirenone on the clinical course, hormonal homeostasis, mental health and quality of life of patients with acne vulgaris

The objective: to determine the additional effect of a drug containing estetrol (E4) and drospirenone (DRSP) on the clinical course, hormonal homeostasis, mental health, and quality of life of reproductive age women with acne vulgaris (AV).Materials and methods. 80 women with AV were enrolled in the study and divided into 2 groups: study group (SG) – 34 women who used a drug containing E4 and DRSP for contraception for 3 months; comparison group (CmpG) – 46 women who were under standard observation for 3 months. Control group included 56 healthy women. The patients were examined before the start of the study and 3 months later. The severity of AV was determined using the Investigator’s Global Assessment (IGA) scale, and mental health and quality of life were also assessed. Concentrations of androgen hormones and sex hormone-binding globulin in blood serum were studied.Results. Patients with AV were found to have mental health disorders, reduced stress tolerance, self-esteem, quality of life, and a significant increase in androgenic hormone levels. The use of a drug with E4/DRSP for contraception in women of SG compared to the CmpG showed additional therapeutic effect. In particular, a significant decrease in androgenic hormone levels, improvement of the clinical picture, reduction in the number of elements of the skin rash and severity of the disease according to the IGA scale were found. This contributed to the improvement of psycho-emotional state and quality of life of women, as evidenced by the high assessment of the benefits and effectiveness of the drug both by patients and doctors.Conclusions. The use of combined oral contraceptives with E4/DRSP for contraception for 3 months in women with AV showed additional therapeutic effect – reducing the level of androgenic hormones and improvement of the clinical picture. This dynamic contributed to the restoration of mental health and improved quality of life of patients, which was confirmed by the high assessment of the drug’s effectiveness by doctors and the women themselves.

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