Maqola

Post-hemorrhagic hydrocephalus in preterm newborns: a literature review (2015-2025)

B. A. IsoboevDGKB DZM «Morozov Children City Clinical Hospital», Moscow, Russia; «Peoples Friendship University of Russia named after Patrice Lumumba», Moscow, Russia; State Budgetary Healthcare Institution Moscow Multidisciplinary Clinical Center «Kommunarka» of the Moscow Department of HealthV. N. UmerenkovDGKB DZM «Morozov Children City Clinical Hospital», Moscow, RussiaM. Zh. ChigibaevDGKB DZM «Morozov Children City Clinical Hospital», Moscow, RussiaK. G. ChmutinDGKB DZM «Morozov Children City Clinical Hospital», Moscow, RussiaА. Е. SamarinState Budgetary Healthcare Institution Moscow Multidisciplinary Clinical Center «Kommunarka» of the Moscow Department of HealthZ. Jallow«Peoples Friendship University of Russia named after Patrice Lumumba», Moscow, RussiaD. B. Nurmyradov«Peoples Friendship University of Russia named after Patrice Lumumba», Moscow, RussiaД.А. АшуровState Budgetary Healthcare Institution Moscow Multidisciplinary Clinical Center «Kommunarka» of the Moscow Department of HealthA.A. GuneevaDGKB DZM «Morozov Children City Clinical Hospital», Moscow, RussiaA. V. KoptevaPirogov Russian National Research Medical University of the Ministry of Health of Russia. 1 Ostrovityanova St., Moscow, Russia, 117997Z. U. ZokirovDGKB DZM «Morozov Children City Clinical Hospital», Moscow, RussiaGayrat Kariev«Republican Scientific Center of Neurosurgery», 40 Khumoyun St., Mirzo — Ulugbek District, Tashkent, Uzbekistan, 100142G. E. ChmutinDGKB DZM «Morozov Children City Clinical Hospital», Moscow, Russia; «Peoples Friendship University of Russia named after Patrice Lumumba», Moscow, Russia

2026

Ochiq kirish: yoʻq

ABI

Annotatsiya

Introduction. Post — hemorrhagic hydrocephalus (PHH) is a severe complication of intraventricular hemorrhage (IVH) in extremely preterm infants, significantly worsening survival rates and neurodevelopmental outcomes. Objective. To analyze current literature (2015–2025) on the pathogenesis, diagnosis, treatment approaches, and outcomes of PHH in preterm infants. Materials and Methods. This review is based on an analysis of peer — reviewed publications, clinical guidelines, and results of randomized trials addressing PHH. Results. The development of PHH involves a complex interplay of mechanisms: mechanical obstruction of cerebrospinal fluid (CSF) pathways by blood clots, neurotoxic effects of hemoglobin breakdown products and iron, as well as neuroinflammation and meningeal fibrosis. The main diagnostic tool is cranial ultrasonography, which allows assessment of IVH severity and progression of ventriculomegaly; MRI is used as a supplementary method. Treatment options include temporary decompression measures (ventricular taps, reservoirs, subgaleal shunts) and permanent CSF shunting (ventriculoperitoneal shunt). Recently, endoscopic techniques (neuroendoscopic lavage, endoscopic third ventriculostomy with choroid plexus coagulation) have been actively investigated. Despite advances in neonatal care, long — term outcomes remain poor: up to 40–50 % of children develop severe disability, mainly due to periventricular leukomalacia. Conclusion. PHH in preterm infants requires a multidisciplinary approach and early intervention. Prevention of severe IVH remains the cornerstone of prophylaxis. Promising future directions include the development of neuroprotective strategies and the refinement of minimally invasive surgical techniques.

Hali tarjima qilinmagan

Identifikatorlar

DOI: 10.33920/med-01-2607-08

Iqtiboslar va manbalar

0 ta iqtibos13 ta foydalanilgan manba