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Cushing's disease caused by an ectopic sphenoid pituitary macroadenoma: a major interdisciplinary challenge in everyday clinical practice

Mateusz TabinDepartment of Endocrinology, Diabetology, and Metabolic Diseases , Fourth Military Clinical Hospital , Wrocław , PolandAnastasija KrzemińskaDepartment of Neurosurgery ,Andrzej KołodziejczykDepartment of Nuclear Medicine , Fourth Military Clinical Hospital , Wrocław , PolandMichał PasternakDepartment of Nuclear Medicine , Fourth Military Clinical Hospital , Wrocław , PolandPaweł GajdzisDepartment of Pathomorphology and Oncological Cytology , Wroclaw Medical University , Wrocław , PolandJoanna BladowskaDepartment of Radiology ,
2026en
ABI

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Ectopic pituitary adenomas (EPAs) are extremely rare (approximately 2% of all pituitary adenomas), non-sellar, benign neoplasms arising from embryonic remnants of the pituitary gland, usually located along the migration path of Rathke's pouch (sphenoid sinus, clivus, or nasopharynx) [1][2][3][4].Most are hormonally active, with ectopic ACTH-secreting pituitary

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