N- and 2-chloro-N-(5-(alkylthio)-1,3,4-thiadiazol-2-yl) acetamides: Synthesis, crystal structure and cytotoxic properties

A series of N-(5-(alkylthio)-1,3,4-thiadiazol-2-yl)acetamides and their 2-chloro analogues were synthesized via the acylation of 2-alkylthio-5-amino-1,3,4-thiadiazoles using acetyl chloride and chloroacetyl chloride. Structural characterization was performed using spectroscopic methods, with selected derivatives further confirmed by single-crystal X-ray analysis. The in vitro cytotoxic activity of the synthesized compounds was evaluated against a panel of cancer cell lines (CCRF-CEM, HEp-2, HeLa, and HBL-100) and normal cells. The most potent derivatives demonstrated IC50 values of approximately 10 μM against CCRF-CEM cells, comparable to the reference drug cytarabine.

Hali tarjima qilinmagan