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Study of the effects of Polyphenol Extracts on Mitochondrial Energy Metabolism and Functional activity of the Liver in Carbon Tetrachloride–Induced Experimental Hepatitis

Saidahon AhmedovaDepartment of Human and Animal Physiology, National University of Uzbekistan Named After Mirzo Ulugbek, Tashkent, 100174, UzbekistanMuzaffar AsrarovInstitute of Biophysics and Biochemistry, National University of Uzbekistan Named After Mirzo Ulugbek, Tashkent 100174, UzbekistanSobitjon MirzakulovDepartment of Human and Animal Physiology, National University of Uzbekistan Named After Mirzo Ulugbek, Tashkent, 100174, UzbekistanAliaksei SysaDepartment of Environmental Chemistry and Biochemistry, A.D. Sakharov International State Environmental Institute, Belarusian State University, Minsk 220070, Belarus

2026

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ABI

Annotatsiya

Mitochondrial malfunction and energy metabolism disruption in liver pathology, particularly experimental hepatitis, have been the subject of more recent research. The impaired mitochondrial respiration and oxidative phosphorylation associated with hepatotoxic injury have been demonstrated to induce decreased ATP generation and hepatocyte dysfunction. Hence, the restoration of mitochondrial bioenergetics is a crucial goal in experimental as well as clinical hepatology. This study investigated whether plant-based polyphenol extracts can treat mitochondrial respiratory dysfunction in experimental hepatitis. A model of carbon tetrachloride (CCl₄)-induced hepatitis was induced in male rats. Polyphenol extracts were administered and evaluated for their impact on mitochondrial function. The performance of mitochondrial respiration, oxidative phosphorylation efficiency, and ATP synthesis were determined by differential centrifugation of isolated liver mitochondria. In experimental hepatitis, the experimental results confirmed significant inhibition of Complex I-dependent respiration and a dramatic decline in mitochondrial respiration. Administration of several polyphenol extracts caused stabilization of the electron transport chain, increased efficiency of oxidative phosphorylation, restoration of mitochondrial respiration, and restoration of ATP production near the control values. It was found that polyphenol extracts not only compensate for the imbalance of mitochondrial respiratory enzymes, but also protect mitochondrial integrity as hepatotoxicity was well described. These findings suggest that the plant-derived polyphenol extracts restore mitochondrial respiration and energy metabolism in experimental hepatitis exerting a hepatoprotective effect. Polyphenol-based correction of mitochondrial dysfunction may represent a promising approach for prevention and therapy of hepatotoxic liver injury.

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Identifikatorlar

DOI: 10.52711/0974-360x.2026.00579

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