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Endophytic Fungi Natural Factories of Novel Bioactive Compounds

Dilmurod MurodullayevInstitute of Microbiology, Academy of Sciences of the Republic of Uzbekistan Tashkent UzbekistanJakhongir MovlanovUniversity of Geological Science, Center of Geoinnovation Technologies Tashkent UzbekistanLiu WeiQilu University of Technology (Shandong Academy of Sciences), Shandong Analysis and Test Center Jinan Shandong ChinaWei LiuShandong Academy of SciencesMaksud IsokovUniversity of Geological Science, Center of Geoinnovation Technologies Tashkent UzbekistanSantosh Kumar BoseDepartment of Horticulture Patuakhali Science and Technology University Dumki Patuakhali BangladeshF. KobilovInstitute of Microbiology, Academy of Sciences of the Republic of Uzbekistan Tashkent UzbekistanZamira DjumayevaSamarkand State Institute of Foreign LanguagesBuston IslamovInstitute of Biochemistry, Samarkand State University University Boulevard 15 Samarkand UzbekistanP Sherkulova JamilaKarshi State University Karshi district UzbekistanZafar MatyakubovKhorezm Mamun Academy Khiva city, Khorezm UzbekistanMuniskhon MeylievaInstitute of Hydrogeology and Engineering Geology University of Geological Science Tashkent UzbekistanМуниса ЭргашеваSamarkand State Medical University Samarkand UzbekistanАбдурахманов, Диёр ШукуруллаевичSamarkand State Medical University Samarkand UzbekistanGuozheng HuangDepartment of Chemical Biology and Pharmaceutical Engineering School of Chemistry and Chemical Engineering, Anhui University of Technology Ma'anshan Anhui ChinaHongchen JiangSchool of Life Sciences Henan University Kaifeng ChinaKakhramon DavranovInstitute of Microbiology, Academy of Sciences of the Republic of Uzbekistan Tashkent UzbekistanGuohui PanState Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology Chinese Academy of Sciences Beijing ChinaNigora RustamovaInstitute of Microbiology, Academy of Sciences of the Republic of Uzbekistan Tashkent Uzbekistan
2026en
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Annotatsiya

Endophytic fungi represent a prolific and chemically diverse source of novel specialized metabolites with significant pharmacological potential. This systematic review examines 118 studies published between 2024 and 2025, reporting the discovery of 242 previously uncharacterized bioactive compounds. These metabolites belong to several major chemical classes, including peptides (4), terpenoids and steroids (58), alkaloids and other nitrogen-containing compounds (51), polyketides (85), lactones (22), ketones (5), chromone compounds (3), and others (9). The genera Aspergillus (28), Penicillium (21), Diaporthe (7), Talaromyces (10), and Trichoderma (6) were identified as the most productive sources. The investigated endophytic fungi were isolated from a wide range of plant hosts and ecological niches, reflecting the extensive biodiversity of endophytic communities. Biological screening demonstrated that a substantial proportion of the tested compounds exhibited diverse bioactivities, including anti-inflammatory, antibacterial, antifungal, antimicroalgal, and cytotoxic effects. Collectively, the remarkable structural diversity and broad biological profiles of metabolites derived from endophytic fungi highlight their strong potential as promising lead scaffolds for future pharmaceutical development.

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DOI
10.1002/cbdv.71710

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